Discovery to improve the lives of brain tumor patients

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  • THE KIM LABORATORY

    The Brain Tumor Center

    Washington University School of Medicine - Siteman Cancer Center

    Department of Neurological Surgery

  • news

    New findings and notable events from the Kim lab

  • UNDERSTANDING GLIOBLASTOMA AND AGGRESSIVE BENIGN BRAIN TUMORS

    Glioblastoma is the most common malignant primary brain tumor in adults. Despite aggressive surgical resection, chemotherapy, and radiation therapy, this disease remains challenging with no cure. We are interested in the molecular mechanisms that control key features of glioblastoma biology. The long-term goal of my laboratory is to leverage these insights for the rational design of novel strategies against this formidable disease.

     

    In addition to malignant disease, there is increasing recognition that even benign brain tumors, like meningiomas, pituitary adenomas (also PitNETs), and vestibular schwannomas, can exhibit aggressive behavior and significantly impact the lives of patients. We are thus motivated to identify and understand the features of these brain tumors that might predict aggressive growth and also be targeted therapeutically.

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    GENETICS

    Our laboratory is interested in developing new strategies to accurately profile patient tumors, including multisector and region-specific approaches, utilizing single cell techniques. We are also focused on establishing innovative model systems using canonical tumor mutations.

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    EPIGENETICS

    Therapy resistance is predominantly defined by epigenetic changes in tumor cells. Glioblastoma stem-like cells represent a dynamic and treatment-resistant cell state influenced by cell-intrinsic and -extrinsic cues. Our laboratory is interested in finding ways to disrupt the epigenetic state that defines these tumor-initiating cells. We are pursuing a variety of approaches, including high-throughput screening, pharmacology, biochemistry, genetics, and material engineering, to accomplish this goal.

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    METABOLISM

    Cancer cells exhibit a dependency on metabolic pathways regulated by nicotinamide adenine dinucleotide (NAD+), which has a well-known role in oxidation-reduction reactions and is an essential component of signaling pathways as a co-factor for NAD+-dependent enzymes. The rate-limiting enzyme in NAD+ synthesis, NAMPT, is highly expressed in glioblastoma tumors. How the regulation of this enzyme interfaces with NAD+-dependent signal transduction networks remains poorly understood in glioblastoma.

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    LASER-BASED IMMUNOTHERAPIES

    Laser therapy, also laser interstitial thermal therapy (LITT), is a minimally invasive tool used by neurosurgeons to kill tumor cells. We have established a mouse laser therapy system to examine the ability of LITT to locally disrupt the blood-brain barrier to augment drug delivery. We are particularly interested in how LITT changes the tumor immune microenvironment.

  • Our Team

    The Kim Lab is committed to supporting diversity of background, thought, and ability. A diverse and inclusive team is a prerequisite for creativity, discovery, and innovation.

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    Albert H. Kim, MD, PhD

    Principal Investigator

    Director, The Brain Tumor Center

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    Diane Mao, MD

    Lab Manager

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    Loren Beck

    Lab Technician

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    Rajanikanth (Rajani) Vangipurapu

    Staff Scientist

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    Rowland Han, MD

    Post-doctoral Fellow

    Neurosurgical resident

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    Hao Chen

    Post-doctoral Fellow

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    Yiwei Fu, MD

    Post-doctoral Fellow

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    David Giles

    Post-doctoral Fellow

     Neurosurgical resident

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    Patrick DeSouza

    MD-PhD Student

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    David Mok

    Bioinformatics Scientist

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    Sangami Pugazenthi

    Medical Student

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    Kyle McGeehan

    MD-PhD Student

    Co-mentored

    with Dr. Alex Stegh

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    Markus Anzaldua-Campos

    MD Student

    WashU School of Medicine

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    Will Leidig

    Undergraduate Student

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    Yoon Shin

    Undergraduate Student

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    Saara Engineer

    Undergraduate Student

    WashU

  • Alumni

    Undergraduate Students

    Alice Turski (2012-2014). Received 2013 Summer Undergraduate Research Fellowship to work in my laboratory.

    John Finlay (Summer 2015).

    Simon Gunter (2015-2016).

    Ross Buchman (Summer 2019).

    Alicia Yang (2020-2022)

    Day Steed (Summer 2022)

    Braxton Sizemore (2021-2023)

    Andrew Hwang (2021-2024)

     

    Graduate Students

    Tatenda Mahlokozera (2020). PhD thesis, MD-PhD program.

    Patrick Desouza (2023). PhD thesis, MD-PhD program.

    Hao Chen (2023). PhD thesis, Neuroscience program.

     

    Medical Students

    Sam Sun (2013-2016). Received the Alpha Omega Alpha Award (2013) and American Brain Tumor Association Summer Fellowship (2014) to work in my lab.

    Ishita Chen (Summer 2013).

    Diane Aum (2014-2016). Received the David Silbert Summer Research Fellowship to work in my laboratory.

    Ramin Lalezari (2014-2016).

    David Dadey (2016-2017).

    Ioana Flores (2017).

    Mounica Pataru (2016-2019). Awarded a NREF Summer Research Fellowship.

    Rukayat Taiwo (2017-2019). Awarded a HHMI Medical Fellowship

     

    Post-doctoral Fellows

    Amit Gujar, PhD (2012-2017). Currently a Staff Scientist in Roel Verhaak Lab, Jackson Laboratories, CT.

    Peter Sylvester, MD (2013-2017). Resident in Neurological Surgery, Washington University.

    Ananth Vellimana, MD (2014-2018). Resident in Neurological Surgery, Washington University.

    Ashwin Kamath, MD (2014-2018). Resident in Neurological Surgery, Washington University.

    Zohny Zohny, MD (2014-2017). Currently a Fellow in Neurological Surgery, Saint Louis University.

    Thomas Beaumont, MD (2014-2016).

    Rory Murphy, MD (2013-2016).

    Santhi Pondugula, PhD (2014-2017).

    Brendan Fong, MD (2017-2019)

    Afshin Salehi, MD (2017-2020)

    Dan Hafez, MD, PhD (2019-2021)

    Devi Annamalai, PhD (2016-2020)

    Bhuvic Patel, MD (2019-2022)

    Satoka Shidoh (2021-2023)

    Rui Sun (2020-2023)

    Ryan Cleary (2021-2023)

    Timothy Woodiwiss (2022-2024)

  • Publications

    2024

    1.             Barrett TF, Patel B, Khan SM, Mullins RDZ, Yim AKY, Pugazenthi S, Mahlokozera T, Zipfel GJ, Herzog JA, Chicoine MR, Wick CC, Durakovic N, Osbun JW, Shew M, Sweeney AD, Patel AJ, Buchman CA, Petti AA, Puram SV, Kim AH. Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state. Nat Commun. 2024 Jan 12;15(1):478. doi: 10.1038/s41467-023-42762-w. PMID: 38216553; PMCID: PMC10786875.

    2.             Kudruk S, Forsyth CM, Dion MZ, Hedlund Orbeck JK, Luo J, Klein RS, Kim AH, Heimberger AB, Mirkin CA, Stegh AH, Artzi N. Multimodal neuro-nanotechnology: Challenging the existing paradigm in glioblastoma therapy. Proc Natl Acad Sci U S A. 2024 Feb 20;121(8):e2306973121. doi: 10.1073/pnas.2306973121. Epub 2024 Feb 12. PMID: 38346200; PMCID: PMC10895370.

    3.             Wang AZ, Mashimo BL, Schaettler MO, Sherpa ND, Leavitt LA, Livingstone AJ, Khan SM, Li M, Anzaldua-Campos MI, Bradley JD, Leuthardt EC, Kim AH, Dowling JL, Chicoine MR, Jones PS, Choi BD, Cahill DP, Carter BS, Petti AA, Johanns TM, Dunn GP. Glioblastoma-infiltrating CD8+ T cells are predominantly a clonally expanded GZMK+ effector population. Cancer Discov. 2024 Feb 28. doi: 10.1158/2159-8290.CD-23-0913. Epub ahead of print. PMID: 38416133.

    4.             Little AS, Karsy M, Evans JJ, Kim W, Pacione DR, Kim AH, Gardner PA, Hendricks BK, Sarris CE, Torok IE, Low TM, Crocker TA, Valappil B, Kanga M, Abdallah H, Collopy S, Fernandez-Miranda JC, Vigo V, Ljubimov VA, Zada G, Garrett NE 3rd, Delery W, Yuen KCJ, Rennert RC, Couldwell WT, Silverstein JM, Kshettry VR, Chicoine MR; RAPID Consortium. Multicenter Registry of Adenomas of the Pituitary and Related Disorders: Initial Description of Cushing Disease Cohort, Surgical Outcomes, and Surgeon Characteristics. Neurosurgery. 2024 Mar 5. doi: 10.1227/neu.0000000000002888. Epub ahead of print. PMID: 38441527.

    5.             Chiang VL, Pugazenthi S, Leidig WA, Rodriguez A, Prabhu S, Haskell-Mendoza AP, Fecci PE, Placantonakis DG, Abram SR, Lega B, Kim AH. Laser interstitial thermal therapy for new and recurrent meningioma: a prospective and retrospective case series. J Neurosurg. 2024 Mar 8:1-11. doi: 10.3171/2023.12.JNS231542. Epub ahead of print. PMID: 38457795.

    2023

    1. Bowman-Kirigin JA, Desai R, Saunders BT, Wang AZ, Schaettler MO, Liu CJ, Livingstone AJ, Kobayashi DK, Durai V, Kretzer NM, Zipfel GJ, Leuthardt EC, Osbun JW, Chicoine MR, Kim AH, Murphy KM, Johanns TM, Zinselmeyer BH, Dunn GP. The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain. Cancer Immunol Res. 2023 Jan 3;11(1):20-37. doi: 10.1158/2326-6066.CIR-22-0098. PMID: 36409838.

    3. Coxon AT, Desai R, Patel PR, Vellimana AK, Willie JT, Dowling JL, Leuthardt EC, Kim AH, Johanns TM, Siegel BA, Dunn GP. A pilot study of lymphoscintigraphy with tracer injection into the human brain. J Cereb Blood Flow Metab. 2023 Mar 30:271678X231160891. doi: 10.1177/0271678X231160891. Epub ahead of print. PMID: 36994857.

    4. Chan M, Tatter S, Chiang V, Fecci P, Strowd R, Prabhu S, Hadjipanayis C, Kirkpatrick J, Sun D, Sinicrope K, Mohammadi AM, Sevak P, Abram S, Kim AH, Leuthardt E, Chao S, Phillips J, Lacroix M, Williams B, Placantonakis D, Silverman J, Baumgartner J, Piccioni D, Laxton A. Efficacy of laser interstitial thermal therapy for biopsy-proven radiation necrosis in radiographically recurrent brain metastases. Neurooncol Adv. 2023 Mar 28;5(1):vdad031. doi: 10.1093/noajnl/vdad031. PMID: 37114245; PMCID: PMC10129388.

    5. Han RH, Johanns TM, Roberts KF, Tao Y, Luo J, Ye Z, Sun P, Blum J, Lin TH, Song SK, Kim AH. Diffusion basis spectrum imaging as an adjunct to conventional MRI leads to earlier diagnosis of high-grade glioma tumor progression versus treatment effect. Neurooncol Adv. 2023 Apr 19;5(1):vdad050. doi: 10.1093/noajnl/vdad050. PMID: 37215950; PMCID: PMC10195207.

    6. McCornack C, Woodiwiss T, Hardi A, Yano H, Kim AH. The function of histone methylation and acetylation regulators in GBM pathophysiology. Front Oncol. 2023 May 2;13:1144184. doi: 10.3389/fonc.2023.1144184. PMID: 37205197; PMCID: PMC10185819.

    7. Sun R, Han R, McCornack C, Khan S, Tabor GT, Chen Y, Hou J, Jiang H, Schoch KM, Mao DD, Cleary R, Yang A, Liu Q, Luo J, Petti A, Miller TM, Ulrich JD, Holtzman DM, Kim AH. TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma. Sci Adv. 2023 May 12;9(19):eade3559. doi: 10.1126/sciadv.ade3559. Epub 2023 May 12. PMID: 37172094; PMCID: PMC10181199.

    8. Ghosh S, Johanns TM, Chheda MG, Liu E, Butt O, Abraham C, Badiyan S, Huang Y, DeNardo D, Kim AH, Hallahan D, Thotala D, Huang J. A pilot phase Ib study to evaluate tadalafil to overcome immunosuppression during chemoradiotherapy for IDH-wild-type glioblastoma. Neurooncol Adv. 2023 Jul 19;5(1):vdad088. doi: 10.1093/noajnl/vdad088. PMID: 37554225; PMCID: PMC10406429.

    9. Aghi MK, Brastianos PK, Kim AH, Kalkanis SN, Tonn JC. Introduction. Update on brain metastases. Neurosurg Focus. 2023 Aug;55(2):E1. doi: 10.3171/2023.6.FOCUS23343. PMID: 37527676.

    10. Luckett PH, Olufawo M, Lamichhane B, Park KY, Dierker D, Verastegui GT, Yang P, Kim AH, Chheda MG, Snyder AZ, Shimony JS, Leuthardt EC. Predicting survival in glioblastoma with multimodal neuroimaging and machine learning. J Neurooncol. 2023 Sep;164(2):309-320. doi: 10.1007/s11060-023-04439-8. Epub 2023 Sep 5. PMID: 37668941; PMCID: PMC10522528.

    11. Terekhanova NV, Karpova A, Liang WW, Strzalkowski A, Chen S, Li Y, Southard-Smith AN, Iglesia MD, Wendl MC, Jayasinghe RG, Liu J, Song Y, Cao S, Houston A, Liu X, Wyczalkowski MA, Lu RJ, Caravan W, Shinkle A, Naser Al Deen N, Herndon JM, Mudd J, Ma C, Sarkar H, Sato K, Ibrahim OM, Mo CK, Chasnoff SE, Porta-Pardo E, Held JM, Pachynski R, Schwarz JK, Gillanders WE, Kim AH, Vij R, DiPersio JF, Puram SV, Chheda MG, Fuh KC, DeNardo DG, Fields RC, Chen F, Raphael BJ, Ding L. Epigenetic regulation during cancer transitions across 11 tumour types. Nature. 2023 Nov;623(7986):432-441. doi: 10.1038/s41586-023-06682-5. Epub 2023 Nov 1. PMID: 37914932; PMCID: PMC10632147.

    12. Pugazenthi S, Price M, De La Vega Gomar R, Kruchko C, Waite KA, Barnholtz-Sloan JS, Walsh KM, Kim AH, Ostrom QT. Association of County-Level Socioeconomic Status with Meningioma Incidence and Outcomes. Neuro Oncol. 2023 Dec 13:noad223. doi: 10.1093/neuonc/noad223. Epub ahead of print. PMID: 38087980.

    2022

    1 Yang PH, Tao Y, Luo J, Paturu M, Lu HC, Ramkissoon S, Heusel JW, Leuthardt EC, Chicoine MR, Dowling JL, Dunn GP, Duncavage E, Dahiya S, Chattherjee AR, Kim AH. Multivariate analysis of associations between clinical sequencing and outcome in glioblastoma. Neurooncol Adv. 2022 Jan 10;4(1):vdac002. doi: 10.1093/noajnl/vdac002. PMID: 35156038; PMCID: PMC8826782.

    2. Hwang H, Huang J, Khaddour K, Butt OH, Ansstas G, Chen J, Katumba RG, Kim AH, Leuthardt EC, Campian JL. Prolonged response of recurrent IDH-wild-type glioblastoma to laser interstitial thermal therapy with pembrolizumab. CNS Oncol. 2022 Jan 19:CNS81. doi: 10.2217/cns-2021-0013. Epub ahead of print. PMID: 35043686.

    3. Patel B, Desai R, Pugazenthi S, Butt OH, Huang J, Kim AH. Identification and Management of Aggressive Meningiomas. Front Oncol. 2022 Mar 23;12:851758. doi: 10.3389/fonc.2022.851758. PMID: 35402234; PMCID: PMC8984123.

    4. Johnson GW, Han RH, Smyth MD, Leuthardt EC, Kim AH. Laser Interstitial Thermal Therapy in Grade 2/3 IDH1/2 Mutant Gliomas: A Preliminary Report and Literature Review. Curr Oncol. 2022 Apr 8;29(4):2550-2563. doi: 10.3390/curroncol29040209. PMID: 35448183; PMCID: PMC9028957.

    5. Wang AZ, Bowman-Kirigin JA, Desai R, Kang LI, Patel PR, Patel B, Khan SM, Bender D, Marlin MC, Liu J, Osbun JW, Leuthardt EC, Chicoine MR, Dacey RG Jr, Zipfel GJ, Kim AH, DeNardo DG, Petti AA, Dunn GP. Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response. Genome Med. 2022 May 10;14(1):49. doi: 10.1186/s13073-022-01051-9. PMID: 35534852; PMCID: PMC9088131.

    6. de Groot JF, Kim AH, Prabhu S, Rao G, Laxton AW, Fecci PE, O'Brien BJ, Sloan A, Chiang V, Tatter SB, Mohammadi AM, Placantonakis DG, Strowd RE, Chen C, Hadjipanayis C, Khasraw M, Sun D, Piccioni D, Sinicrope KD, Campian JL, Kurz SC, Williams B, Smith K, Tovar-Spinoza Z, Leuthardt EC. Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrent IDH wild-type glioblastoma. Neurooncol Adv. 2022 Apr 6;4(1):vdac040. doi: 10.1093/noajnl/vdac040. PMID: 35611270; PMCID: PMC9122789.

    7. Mao DD, Cleary RT, Gujar A, Mahlokozera T, Kim AH. CDC20 regulates sensitivity to chemotherapy and radiation in glioblastoma stem cells. PLoS One. 2022 Jun 23;17(6):e0270251. doi: 10.1371/journal.pone.0270251. PMID: 35737702; PMCID: PMC9223386.

    8. Grabowski MM, Srinivasan ES, Vaios EJ, Sankey EW, Otvos B, Krivosheya D, Scott A, Olufawo M, Ma J, Fomchenko EI, Herndon JE, Kim AH, Chiang VL, Chen CC, Leuthardt EC, Barnett GH, Kirkpatrick JP, Mohammadi AM, Fecci PE. Combination laser interstitial thermal therapy plus stereotactic radiotherapy increases time to progression for biopsy-proven recurrent brain metastases. Neurooncol Adv. 2022 Jun 2;4(1):vdac086. doi: 10.1093/noajnl/vdac086. PMID: 35795470; PMCID: PMC9248774.

    9. Cross KA, Desai R, Vellimana A, Liu Y, Rich K, Zipfel G, Dacey R, Chicoine M, Klatt-Cromwell C, McJunkin J, Pipkorn P, Schneider JS, Silverstein J, Kim AH. Surgery for Pituitary Tumor Apoplexy Is Associated with Rapid Headache and Cranial Nerve Improvement. Curr Oncol. 2022 Jul 12;29(7):4914-4922. doi: 10.3390/curroncol29070390. PMID: 35877250; PMCID: PMC9319222.

    10. Broestl L, Warrington NM, Grandison L, Abou-Antoun T, Tung O, Shenoy S, Tallman MM, Rhee G, Yang W, Sponagel J, Yang L, Kfoury-Beaumont N, Hill CM, Qanni SA, Mao DD, Kim AH, Stewart SA, Venere M, Luo J, Rubin JB. Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma. Commun Biol. 2022 Aug 2;5(1):781. doi: 10.1038/s42003-022-03743-9. PMID: 35918603; PMCID: PMC9345919.

    11. Sun R, Kim AH. The multifaceted mechanisms of malignant glioblastoma progression and clinical implications. Cancer Metastasis Rev. 2022 Aug 3. doi: 10.1007/s10555-022-10051-5. Epub ahead of print. PMID: 35920986.

    12. Cui Zhou D, Jayasinghe RG, Chen S, Herndon JM, Iglesia MD, Navale P, Wendl MC, Caravan W, Sato K, Storrs E, Mo CK, Liu J, Southard-Smith AN, Wu Y, Naser Al Deen N, Baer JM, Fulton RS, Wyczalkowski MA, Liu R, Fronick CC, Fulton LA, Shinkle A, Thammavong L, Zhu H, Sun H, Wang LB, Li Y, Zuo C, McMichael JF, Davies SR, Appelbaum EL, Robbins KJ, Chasnoff SE, Yang X, Reeb AN, Oh C, Serasanambati M, Lal P, Varghese R, Mashl JR, Ponce J, Terekhanova NV, Yao L, Wang F, Chen L, Schnaubelt M, Lu RJ, Schwarz JK, Puram SV, Kim AH, Song SK, Shoghi KI, Lau KS, Ju T, Chen K, Chatterjee D, Hawkins WG, Zhang H, Achilefu S, Chheda MG, Oh ST, Gillanders WE, Chen F, DeNardo DG, Fields RC, Ding L. Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer. Nat Genet. 2022 Aug 22. doi: 10.1038/s41588-022-01157-1. Epub ahead of print. PMID: 35995947.

    13. Li YD, Coxon AT, Huang J, Abraham CD, Dowling JL, Leuthardt EC, Dunn GP, Kim AH, Dacey RG, Zipfel GJ, Evans J, Filiput EA, Chicoine MR. Neoadjuvant stereotactic radiosurgery for brain metastases: a new paradigm. Neurosurg Focus. 2022 Nov;53(5):E8. doi: 10.3171/2022.8.FOCUS22367. PMID: 36321291.

    2021

    1. Galdieri L, Jash A, Malkova O, Mao DD, DeSouza PA, Chu YE, Salter A, Campian JL, Naegle KM, Brennan CW, Wakimoto H, Oh ST, Kim AH, Chheda MG. Defining phenotypic and functional heterogeneity of glioblastoma stem cells by mass cytometry. JCI Insight. 2021 Jan 5:128456. doi: 10.1172/jci.insight.128456. Epub ahead of print. PMID: 33400685.

    2. DeSouza PA, Qu X, Chen H, Patel B, Maher CA, Kim AH. Long, Noncoding RNA Dysregulation in Glioblastoma. Cancers (Basel). 2021 Mar 31;13(7):1604. doi: 10.3390/cancers13071604. PMID: 33807183; PMCID: PMC8037018.

    3. Wang LB, Karpova A, Gritsenko MA, Kyle JE, Cao S, Li Y, Rykunov D, Colaprico A, Rothstein JH, Hong R, Stathias V, Cornwell M, Petralia F, Wu Y, Reva B, Krug K, Pugliese P, Kawaler E, Olsen LK, Liang WW, Song X, Dou Y, Wendl MC, Caravan W, Liu W, Cui Zhou D, Ji J, Tsai CF, Petyuk VA, Moon J, Ma W, Chu RK, Weitz KK, Moore RJ, Monroe ME, Zhao R, Yang X, Yoo S, Krek A, Demopoulos A, Zhu H, Wyczalkowski MA, McMichael JF, Henderson BL, Lindgren CM, Boekweg H, Lu S, Baral J, Yao L, Stratton KG, Bramer LM, Zink E, Couvillion SP, Bloodsworth KJ, Satpathy S, Sieh W, Boca SM, Schürer S, Chen F, Wiznerowicz M, Ketchum KA, Boja ES, Kinsinger CR, Robles AI, Hiltke T, Thiagarajan M, Nesvizhskii AI, Zhang B, Mani DR, Ceccarelli M, Chen XS, Cottingham SL, Li QK, Kim AH, Fenyö D, Ruggles KV, Rodriguez H, Mesri M, Payne SH, Resnick AC, Wang P, Smith RD, Iavarone A, Chheda MG, Barnholtz-Sloan JS, Rodland KD, Liu T, Ding L; Clinical Proteomic Tumor Analysis Consortium. Proteogenomic and metabolomic characterization of human glioblastoma. Cancer Cell. 2021 Apr 12;39(4):509-528.e20. doi: 10.1016/j.ccell.2021.01.006. Epub 2021 Feb 11. PMID: 33577785; PMCID: PMC8044053.

    4. Chicoine MR, Kim AH. Commentary: Adjuvant Radiotherapy Versus Watchful Waiting for World Health Organization Grade II Atypical Meningioma: A Single-Institution Experience. Neurosurgery. 2021 Apr 15;88(5):E443-E444. doi: 10.1093/neuros/nyab048. PMID: 33611601.

    5. Chicoine MR, Kim AH. In Reply: Commentary: Adjuvant Radiotherapy Versus Watchful Waiting for World Health Organization Grade II Atypical Meningioma: A Single-Institution Experience. Neurosurgery. 2021 Jun 7:nyab207. doi: 10.1093/neuros/nyab207. Epub ahead of print. PMID: 34098571.

    6. Nduom EK, Gephart MH, Chheda MG, Suva ML, Amankulor N, Battiste JD, Campian JL, Dacey RG, Das S, Fecci PE, Hadjipanayis CG, Hoang KB, Jalali A, Orringer D, Patel AJ, Placantonakis D, Rodriguez A, Yang I, Yu JS, Zipfel GJ, Dunn GP, Leuthardt EC, Kim AH. Re-evaluating Biopsy for Recurrent Glioblastoma: A Position Statement by the Christopher Davidson Forum Investigators. Neurosurgery. 2021 Jun 15;89(1):129-132. doi: 10.1093/neuros/nyab063. PMID: 33862619.

    7. Ma S, Rudra S, Campian JL, Chheda MG, Johanns TM, Ansstas G, Abraham CD, Chicoine MR, Leuthardt EC, Dowling JL, Dunn GP, Kim AH, Huang J. Salvage therapies for radiation-relapsed isocitrate dehydrogenase-mutant astrocytoma and 1p/19q codeleted oligodendroglioma. Neurooncol Adv. 2021 Jun 18;3(1):vdab081. doi: 10.1093/noajnl/vdab081. PMID: 34345818; PMCID: PMC8324173.

    8. Hyeon JW, Kim AH, Yano H. Epigenetic regulation in Huntington's disease. Neurochem Int. 2021 Sep;148:105074. doi: 10.1016/j.neuint.2021.105074. Epub 2021 May 24. PMID: 34038804.

    9. Sato C, Mallipeddi N, Ghoshal N, Wright BA, Day GS, Davis AA, Kim AH, Zipfel GJ, Bateman RJ, Gabelle A, Barthélemy NR. MAPT R406W increases tau T217 phosphorylation in absence of amyloid pathology. Ann Clin Transl Neurol. 2021 Aug 2. doi: 10.1002/acn3.51435. Epub ahead of print. PMID: 34342183.

    10. Schaettler MO, Richters MM, Wang AZ, Skidmore ZL, Fisk B, Miller KE, Vickery TL, Kim AH, Chicoine MR, Osbun JW, Leuthardt EC, Dowling JL, Zipfel GJ, Dacey RG, Lu HC, Johanns TM, Griffith OL, Mardis ER, Griffith M, Dunn GP. Characterization of the Genomic and Immunological Diversity of Malignant Brain Tumors Through Multi-Sector Analysis. Cancer Discov. 2021 Oct 5:candisc.0291.2021. doi: 10.1158/2159-8290.CD-21-0291. Epub ahead of print. PMID: 34610950.

    11. Smith HJ, Durakovic N, Patel B, Varagur K, Gupta S, Khan AM, Kallogjeri D, Kim AH, Piccirillo JF, Buchman CA. Clinical Staging to Estimate the Probability of Severe Postoperative Complications in Patients With Vestibular Schwannoma. JAMA Otolaryngol Head Neck Surg. 2021 Oct 7:e212626. doi: 10.1001/jamaoto.2021.2626. Epub ahead of print. PMID: 34617972; PMCID: PMC8498930.

    12. McNulty SN, Schwetye KE, Ferguson C, Storer CE, Ansstas G, Kim AH, Gutmann DH, Rubin JB, Head RD, Dahiya S. BRAF mutations may identify a clinically distinct subset of glioblastoma. Sci Rep. 2021 Oct 8;11(1):19999. doi: 10.1038/s41598-021-99278-w. PMID: 34625582; PMCID: PMC8501013.

    13. Mahlokozera T, Patel B, Chen H, Desouza P, Qu X, Mao DD, Hafez D, Yang W, Taiwo R, Paturu M, Salehi A, Gujar AD, Dunn GP, Mosammaparast N, Petti AA, Yano H, Kim AH. Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma. Nat Commun. 2021 Nov 3;12(1):6321. doi: 10.1038/s41467-021-26653-6. PMID: 34732716.

    14. Butt OH, Zhou AY, Huang J, Leidig WA, Silberstein AE, Chheda MG, Johanns TM, Ansstas G, Liu J, Talcott G, Nakiwala R, Shimony JS, Kim AH, Leuthardt EC, Tran DD, Campian JL. A phase II study of laser interstitial thermal therapy combined with doxorubicin in patients with recurrent glioblastoma. Neurooncol Adv. 2021 Nov 15;3(1):vdab164. doi: 10.1093/noajnl/vdab164. PMID: 34988450; PMCID: PMC8694207.

    2020

    1. Patel B, Kim AH. Laser Interstitial Thermal Therapy. Mo Med. 2020 Jan-Feb;117(1):50-55. PubMed PMID: 32158050; PubMed Central PMCID: PMC7023945.

    2. Patel B, Taiwo R, Kim AH, Dunn GP. TERT, a promoter of CNS malignancies. Neurooncol Adv. 2020 Jan-Dec;2(1):vdaa025. doi: 10.1093/noajnl/vdaa025. Epub 2020 Feb 28. Review. PubMed PMID: 32226942; PubMed Central PMCID: PMC7086299.

    3. Yahanda AT, Patel B, Sutherland G, Honeycutt J, Jensen RL, Smyth MD, Limbrick DD Jr, Dacey RG Jr, Dowling JL, Dunn GP, Kim AH, Leuthardt EC, Rich KM, Zipfel GJ, Leonard JR, Cahill DP, Shah MV, Abram SR, Evans J, Tao Y, Chicoine MR. A Multi-Institutional Analysis of Factors Influencing Surgical Outcomes for Patients with Newly Diagnosed Grade I Gliomas. World Neurosurg. 2020 Mar;135:e754-e764. doi: 10.1016/j.wneu.2019.12.156. Epub 2019 Dec 31. PubMed PMID: 31901497.

    4. Rennert RC, Khan U, Bartek J, Tatter SB, Field M, Toyota B, Fecci PE, Judy K, Mohammadi AM, Landazuri P, Sloan AE, Kim AH, Leuthardt EC, Chen CC. Laser Ablation of Abnormal Neurological Tissue Using Robotic Neuroblate System (LAANTERN): Procedural Safety and Hospitalization. Neurosurgery. 2020 Apr 1;86(4):538-547. doi: 10.1093/neuros/nyz141. PubMed PMID: 31076762.

    5. Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, Gray JW, Guinney J, Hanlon SE, Hughes SK, Hwang ES, Iacobuzio-Donahue CA, Jané-Valbuena J, Johnson BE, Lau KS, Lively T, Mazzilli SA, Pe'er D, Santagata S, Shalek AK, Schapiro D, Snyder MP, Sorger PK, Spira AE, Srivastava S, Tan K, West RB, Williams EH; Human Tumor Atlas Network. The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution. Cell. 2020 Apr 16;181(2):236-249. doi: 10.1016/j.cell.2020.03.053.

    6. Kim AH, Tatter S, Rao G, Prabhu S, Chen C, Fecci P, Chiang V, Smith K, Williams BJ, Mohammadi AM, Judy K, Sloan A, Tovar-Spinoza Z, Baumgartner J, Hadjipanayis C, Leuthardt EC. Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System (LAANTERN): 12-Month Outcomes and Quality of Life After Brain Tumor Ablation. Neurosurgery. 2020 Apr 21;nyaa071. doi: 10.1093/neuros/nyaa071. Online ahead of print.

    7. Hwang JY, Aum DJ, Chicoine MR, Dacey RG Jr, Osbun JW, Rich KM, Zipfel GJ, Klatt-Cromwell CN, McJunkin JL, Pipkorn P, Schneider JS, Silverstein JM, Kim AH. Axis-specific Analysis and Predictors of Endocrine Recovery and Deficits for Non-Functioning Pituitary Adenomas Undergoing Endoscopic Transsphenoidal Surgery. Pituitary. 2020 May 9. doi: 10.1007/s11102-020-01045-z. Online ahead of print.

    8. Salehi A, Paturu MR, Patel B, Cain MD, Mahlokozera T, Yang AB, Lin TH, Leuthardt EC, Yano H, Song SK, Klein RS, Schmidt R, Kim AH. Therapeutic Enhancement of Blood-Brain and Blood-Tumor Barrier Permeability by Laser Interstitial Thermal Therapy. Neuro-Oncology Advances. Jun 2020. doi:10.1093/noajnl/vdaa071.

    9. Fu Y, Liu CJ, Kobayashi DK, Johanns TM, Bowman-Kirigin JA, Schaettler MO, Mao DD, Bender D, Kelley DG, Uppaluri R, Bi WL, Dunn IF, Tao Y, Luo J, Kim AH, Dunn GP. GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors. Sci Rep. 2020 Jun 3;10(1):9027. doi: 10.1038/s41598-020-65915-z. PMID: 32493985; PMCID: PMC7271235.

    10. Patel B, Yang PH, Kim AH. The effect of thermal therapy on the blood-brain barrier and blood-tumor barrier. Int J Hyperthermia. 2020 Jul;37(2):35-43. doi: 10.1080/02656736.2020.1783461. PMID: 32672118.

    11. Ye Z, Price RL, Liu X, Lin J, Yang Q, Sun P, Wu AT, Wang L, Han RH, Song C, Yang R, Gary SE, Mao DD, Wallendorf M, Campian JL, Li JS, Dahiya S,* Kim AH,* Song SV. Diffusion Histology Imaging Combining Diffusion Basis Spectrum Imaging (DBSI) and Machine Learning Improves Detection and Classification of Glioblastoma Pathology. Clin Cancer Res. 2020 Jul 21:clincanres.0736.2020. doi: 10.1158/1078-0432.CCR-20-0736. Epub ahead of print. PMID: 32694155. *corresponding authors.

    12. Yahanda AT, Patel B, Shah AS, Cahill DP, Sutherland G, Honeycutt J, Jensen RL, Rich KM, Dowling JL, Limbrick DD, Dacey RG, Kim AH, Leuthardt EC, Dunn GP, Zipfel GJ, Leonard JR, Smyth MD, Shah MV, Abram SR, Evans J, Chicoine MR. Impact of Intraoperative Magnetic Resonance Imaging and Other Factors on Surgical Outcomes for Newly Diagnosed Grade II Astrocytomas and Oligodendrogliomas: A Multicenter Study. Neurosurgery. 2020 Jul 27:nyaa320. doi: 10.1093/neuros/nyaa320. Epub ahead of print. PMID: 32717067.

    13. Yahanda AT, Patel B, Shah AS, Cahill DP, Sutherland G, Honeycutt J, Jensen RL, Rich KM, Dowling JL, Limbrick DD, Dacey RG, Kim AH, Leuthardt EC, Dunn GP, Zipfel GJ, Leonard JR, Smyth MD, Shah MV, Abram SR, Evans J, Chicoine MR. Impact of Intraoperative Magnetic Resonance Imaging and Other Factors on Surgical Outcomes for Newly Diagnosed Grade II Astrocytomas and Oligodendrogliomas: A Multicenter Study. Neurosurgery. 2020 Jul 27:nyaa320. doi: 10.1093/neuros/nyaa320. Epub ahead of print. PMID: 32717067.

    14. Shah AS, Yahanda AT, Sylvester PT, Evans J, Dunn GP, Jensen RL, Honeycutt J, Cahill DP, Sutherland GR, Oswood M, Shah M, Abram SR, Rich KM, Dowling JL, Leuthardt EC, Dacey RG, Kim AH, Zipfel GJ, Limbrick DD, Smyth MD, Leonard J, Chicoine MR. Using Histopathology to Assess the Reliability of Intraoperative Magnetic Resonance Imaging in Guiding Additional Brain Tumor Resection: A Multicenter Study. Neurosurgery. 2020 Dec 15;88(1):E49-E59. doi: 10.1093/neuros/nyaa338. PMID: 32803226.

    15. Shah AS, Sylvester PT, Yahanda AT, Vellimana AK, Dunn GP, Evans J, Rich KM, Dowling JL, Leuthardt EC, Dacey RG, Kim AH, Grubb RL, Zipfel GJ, Oswood M, Jensen RL, Sutherland GR, Cahill DP, Abram SR, Honeycutt J, Shah M, Tao Y, Chicoine MR. Intraoperative MRI for newly diagnosed supratentorial glioblastoma: a multicenter-registry comparative study to conventional surgery. J Neurosurg. 2020 Oct 9:1-10. doi: 10.3171/2020.6.JNS19287. Epub ahead of print. PMID: 33035996.

    16. Ma S, Rudra S, Campian JL, Dahiya S, Dunn GP, Johanns T, Goldstein M, Kim AH, Huang J. Prognostic impact of CDKN2A/B deletion, TERT mutation, and EGFR amplification on histological and molecular IDH-wildtype glioblastoma. Neurooncol Adv. 2020 Sep 18;2(1):vdaa126. doi: 10.1093/noajnl/vdaa126. PMID: 33235995; PMCID: PMC7668466.

    17. Kennedy WR, DeWees TA, Acharya S, Mahmood M, Knutson NC, Goddu SM, Kavanaugh JA, Mitchell TJ, Rich KM, Kim AH, Leuthardt EC, Dowling JL, Dunn GP, Chicoine MR, Perkins SM, Huang J, Tsien CI, Robinson CG, Abraham CD. Internal dose escalation associated with increased local control for melanoma brain metastases treated with stereotactic radiosurgery. J Neurosurg. 2020 Dec 11:1-7. doi: 10.3171/2020.7.JNS192210. Epub ahead of print. PMID: 33307528.

    2019

    1. Taylor JW, Armstrong T, Kim AH, Venere M, Acquaye A, Schrag D, Wen PY. The lomustine crisis: awareness and impact of the 1500% price hike. Neuro Oncol. 2019 Jan 1;21(1):1-3. doi: 10.1093/neuonc/noy189. PubMed PMID: 30590836; PubMed Central PMCID: PMC6303421.

    2. Yang W, Warrington NM, Taylor SJ, Whitmire P, Carrasco E, Singleton KW, Wu N, Lathia JD, Berens ME, Kim AH, Barnholtz-Sloan JS, Swanson KR, Luo J, Rubin JB. Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data. Sci Transl Med. 2019 Jan 2;11(473). doi: 10.1126/scitranslmed.aao5253. PubMed PMID: 30602536; PubMed Central PMCID: PMC6502224.

    3. Kamath AA, Friedman DD, Akbari SHA, Kim AH, Tao Y, Luo J, Leuthardt EC. Glioblastoma Treated With Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy: Safety, Efficacy, and Outcomes. Neurosurgery. 2019 Apr 1;84(4):836-843. doi: 10.1093/neuros/nyy375. PubMed PMID: 30137606; PubMed Central PMCID: PMC6425465.

    4. Silverstein JM, Goss CW, Kim AH. In Reply: Withholding Perioperative Steroids in Patients Undergoing Transsphenoidal Resection for Pituitary Disease: Randomized Prospective Clinical Trial to Assess Safety. Neurosurgery. 2019 Jul 1;85(1):E162. doi: 10.1093/neuros/nyz108. PubMed PMID: 30989222.

    5. Sterl K, Thompson B, Goss CW, Dacey RG, Rich KM, Zipfel GJ, Chicoine MR, Kim AH, Silverstein JM. Withholding Perioperative Steroids in Patients Undergoing Transsphenoidal Resection for Pituitary Disease: Randomized Prospective Clinical Trial to Assess Safety. Neurosurgery. 2019 Aug 1;85(2):E226-E232. doi: 10.1093/neuros/nyy479. PubMed PMID: 30325449.

    6. Han RH, Dunn GP, Chheda MG, Kim AH. The impact of systemic precision medicine and immunotherapy treatments on brain metastases. Oncotarget. 2019 Nov 19;10(62):6739-6753. doi: 10.18632/oncotarget.27328. eCollection 2019 Nov 19. PubMed PMID: 31803366; PubMed Central PMCID: PMC6877099.

    7. Mohammadi AM, Sharma M, Beaumont TL, Juarez KO, Kemeny H, Dechant C, Seas A, Sarmey N, Lee BS, Jia X, Fecci PE, Baehring J, Moliterno J, Chiang VL, Ahluwalia MS, Kim AH, Barnett GH, Leuthardt EC. Upfront Magnetic Resonance Imaging-Guided Stereotactic Laser-Ablation in Newly Diagnosed Glioblastoma: A Multicenter Review of Survival Outcomes Compared to a Matched Cohort of Biopsy-Only Patients. Neurosurgery. 2019 Dec 1;85(6):762-772. doi: 10.1093/neuros/nyy449. PubMed PMID: 30476325; PubMed Central PMCID: PMC7054708.

    8. Hacker CD, Roland JL, Kim AH, Shimony JS, Leuthardt EC. Resting-state network mapping in neurosurgical practice: a review.Neurosurg Focus. 2019 Dec 1;47(6):E15. doi: 10.3171/2019.9.FOCUS19656. PubMed PMID: 31786561.

    2018

    1. Kamath AA, Friedman DD, Hacker CD, Smyth MD, Limbrick DD Jr, Kim AH, Hawasli AH, Leuthardt EC. MRI-Guided Interstitial Laser Ablation for Intracranial Lesions: A Large Single-Institution Experience of 133 Cases. Stereotact Funct Neurosurg. 2017;95(6):417-428. doi: 10.1159/000485387. Epub 2018 Jan 17. PubMed PMID: 29339639.

    2. Strowd RE, Kim AH, Wen PY. Meeting Update-Society for Neuro-Oncology 2017 Annual Meeting. Neuro Oncol. 2018 Jan 22;20(2):156-159. doi: 10.1093/neuonc/nox239. PubMed PMID: 29365203; PubMed Central PMCID: PMC5777479.

    3. Barrow AD, Edeling MA, Trifonov V, Luo J, Goyal P, Bohl B, Bando JK, Kim AH, Walker J, Andahazy M, Bugatti M, Melocchi L, Vermi W, Fremont DH, Cox S, Cella M, Schmedt C, Colonna M. Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor. Cell. 2018 Jan 25;172(3):534-548.e19. doi: 10.1016/j.cell.2017.11.037. Epub 2017 Dec 21. PubMed PMID: 29275861; PubMed Central PMCID: PMC6684025.

    4. Reynolds MR, Arias EJ, Derdeyn CP, Kim AH. Transorbital intracranial penetrating trauma with carotid artery injury: a multidisciplinary approach to management. J Neurosurg Sci. 2018 Feb;62(1):89-91. doi: 10.23736/S0390-5616.16.03643-2. PubMed PMID: 29239162.

    5. Mahlokozera T, Vellimana AK, Li T, Mao DD, Zohny ZS, Kim DH, Tran DD, Marcus DS, Fouke SJ, Campian JL, Dunn GP, Miller CA, Kim AH. Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastoma. Neuro Oncol. 2018 Mar 27;20(4):472-483. doi: 10.1093/neuonc/nox232. PubMed PMID: 29244145; PubMed Central PMCID: PMC5909635.

    6. Abraham C, Garsa A, Badiyan SN, Drzymala R, Yang D, DeWees T, Tsien C, Dowling JL, Rich KM, Chicoine MR, Kim AH, Leuthardt EC, Robinson C. Internal dose escalation is associated with increased local control for non-small cell lung cancer (NSCLC) brain metastases treated with stereotactic radiosurgery (SRS). Adv Radiat Oncol. 2018 Apr-Jun;3(2):146-153. doi: 10.1016/j.adro.2017.11.003. eCollection 2018 Apr-Jun. PubMed PMID: 29904739; PubMed Central PMCID: PMC6000027.

    7. Huang J, Campian JL, Gujar AD, Tsien C, Ansstas G, Tran DD, DeWees TA, Lockhart AC, Kim AH. Final results of a phase I dose-escalation, dose-expansion study of adding disulfiram with or without copper to adjuvant temozolomide for newly diagnosed glioblastoma. J Neurooncol. 2018 May;138(1):105-111. doi: 10.1007/s11060-018-2775-y. Epub 2018 Jan 27. PubMed PMID: 29374809.

    8. Taiwo R, Mahlokozera T, Kim AH. Stem nourished by branches: glioblastomas co-opt classic neurotrophic factor signaling to maintain stem-like cell pool. Stem Cell Investig. 2018;5:22. doi: 10.21037/sci.2018.07.01. eCollection 2018. PubMed PMID: 30148155; PubMed Central PMCID: PMC6087708.

    9. Pan Y, Zhu Y, Yang W, Tycksen E, Liu S, Palucki J, Zhu L, Sasaki Y, Sharma MK, Kim AH, Zhang B, Yano H. The role of Twist1 in mutant huntingtin-induced transcriptional alterations and neurotoxicity. J Biol Chem. 2018 Jul 27;293(30):11850-11866. doi: 10.1074/jbc.RA117.001211. Epub 2018 Jun 11. PubMed PMID: 29891550; PubMed Central PMCID: PMC6066321.

    10. Gabani P, Fischer-Valuck BW, Johanns TM, Hernandez-Aya LF, Keller JW, Rich KM, Kim AH, Dunn GP, Robinson CG, Chicoine MR, Huang J, Abraham CD. Stereotactic radiosurgery and immunotherapy in melanoma brain metastases: Patterns of care and treatment outcomes. Radiother Oncol. 2018 Aug;128(2):266-273. doi: 10.1016/j.radonc.2018.06.017. Epub 2018 Jun 27. PubMed PMID: 29960685.

    11. Lin AJ, Hui C, Dahiya S, Lu HC, Kim AH, Campian JL, Tsien C, Zipfel GJ, Rich KM, Chicoine M, Huang J. Radiologic Response and Disease Control of Recurrent Intracranial Meningiomas Treated With Reirradiation. Int J Radiat Oncol Biol Phys. 2018 Sep 1;102(1):194-203. doi: 10.1016/j.ijrobp.2018.05.011. Epub 2018 Jun 30. PubMed PMID: 29970312.

    12. Beaumont TL, Mohammadi AM, Kim AH, Barnett GH, Leuthardt EC. Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy for Glioblastoma of the Corpus Callosum. Neurosurgery. 2018 Sep 1;83(3):556-565. doi: 10.1093/neuros/nyx518. PubMed PMID: 29438526; PubMed Central PMCID: PMC6939409.

    13. Salehi A, Kamath AA, Leuthardt EC, Kim AH. Management of Intracranial Metastatic Disease With Laser Interstitial Thermal Therapy.Front Oncol. 2018;8:499. doi: 10.3389/fonc.2018.00499. eCollection 2018. PubMed PMID: 30430083; PubMed Central PMCID: PMC6220072.

    14. McNulty SN, Schwetye K, Goldstein M, Carter J, Schmidt RE, Ansstas G, Tsien CI, Kim AH, Dahiya S. Analysis of point mutations and copy number variation in Grade II and III meningioma. Exp Mol Pathol. 2018 Dec;105(3):328-333. doi: 10.1016/j.yexmp.2018.10.007. Epub 2018 Oct 11. PubMed PMID: 30316860.

    15. Taiwo R, Mahlokozera T, Kim AH. Erratum to stem nourished by branches: glioblastomas co-opt classic neurotrophic factor signaling to maintain stem-like cell pool. Stem Cell Investig. 2018;5:48. doi: 10.21037/sci.2018.11.06. eCollection 2018. PubMed PMID: 30701183; PubMed Central PMCID: PMC6327164.

    2017

    1. Strowd RE, Kim AH. Meeting update-Society for Neuro-Oncology 2016 annual meeting. Neuro Oncol. 2017 Feb 1;19(2):150-152. doi: 10.1093/neuonc/now295. PubMed PMID: 28391300; PubMed Central PMCID: PMC5464251.

    2. Leuthardt EC, Voigt J, Kim AH, Sylvester P. A Single-Center Cost Analysis of Treating Primary and Metastatic Brain Cancers with Either Brain Laser Interstitial Thermal Therapy (LITT) or Craniotomy. Pharmacoecon Open. 2017 Mar;1(1):53-63. doi: 10.1007/s41669-016-0003-2. PubMed PMID: 29442297; PubMed Central PMCID: PMC5689033.

    3. Rao YJ, Hassanzadeh C, Fischer-Valuck B, Chicoine MR, Kim AH, Perkins SM, Huang J. Patterns of care and treatment outcomes of patients with Craniopharyngioma in the national cancer database. J Neurooncol. 2017 Mar;132(1):109-117. doi: 10.1007/s11060-016-2342-3. Epub 2016 Dec 23. PubMed PMID: 28012064.

    4. Kang P, Bucelli RC, Ferguson CJ, Corbo JC, Kim AH, Day GS. Teaching NeuroImages: Cerebral amyloid angiopathy-related inflammation presenting with isolated leptomeningitis. Neurology. 2017 Aug 8;89(6):e66-e67. doi: 10.1212/WNL.0000000000004218. PubMed PMID: 28784645.

    5. Das S, Kim AH, Chang S, Berger MS. Management of Elderly Patients with Glioblastoma after CE.6. Front Oncol. 2017;7:196. doi: 10.3389/fonc.2017.00196. eCollection 2017. PubMed PMID: 28913179; PubMed Central PMCID: PMC5582080.

    2016

    1. Dadey DY, Kapoor V, Khudanyan A, Urano F, Kim AH, Thotala D, Hallahan DE. The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma. Oncotarget. 2016 Jan 12;7(2):2080-92. doi: 10.18632/oncotarget.6712. PubMed PMID: 26716508; PubMed Central PMCID: PMC4811517.

    2. Kang SK, Murphy RK, Hwang SW, Lee SM, Harburg DV, Krueger NA, Shin J, Gamble P, Cheng H, Yu S, Liu Z, McCall JG, Stephen M, Ying H, Kim J, Park G, Webb RC, Lee CH, Chung S, Wie DS, Gujar AD, Vemulapalli B, Kim AH, Lee KM, Cheng J, Huang Y, Lee SH, Braun PV, Ray WZ, Rogers JA. Bioresorbable silicon electronic sensors for the brain. Nature. 2016 Feb 4;530(7588):71-6. doi: 10.1038/nature16492. Epub 2016 Jan 18. PubMed PMID: 26779949.

    3. Leuthardt EC, Duan C, Kim MJ, Campian JL, Kim AH, Miller-Thomas MM, Shimony JS, Tran DD. Hyperthermic Laser Ablation of Recurrent Glioblastoma Leads to Temporary Disruption of the Peritumoral Blood Brain Barrier. PLoS One. 2016;11(2):e0148613. doi: 10.1371/journal.pone.0148613. eCollection 2016. PubMed PMID: 26910903; PubMed Central PMCID: PMC4766093.

    4. Gujar AD, Yano H, Kim AH. The CDC20-APC/SOX2 signaling axis: An achilles' heel for glioblastoma. Mol Cell Oncol. 2016 May;3(3):e1075644. doi: 10.1080/23723556.2015.1075644. eCollection 2016 May. PubMed PMID: 27314081; PubMed Central PMCID: PMC4909416.

    5. Huang J, Campian JL, Gujar AD, Tran DD, Lockhart AC, DeWees TA, Tsien CI, Kim AH. A phase I study to repurpose disulfiram in combination with temozolomide to treat newly diagnosed glioblastoma after chemoradiotherapy. J Neurooncol. 2016 Jun;128(2):259-66. doi: 10.1007/s11060-016-2104-2. Epub 2016 Mar 10. PubMed PMID: 26966095.

    6. Johanns TM, Fu Y, Kobayashi DK, Mei Y, Dunn IF, Mao DD, Kim AH, Dunn GP. High incidence of TERT mutation in brain tumor cell lines. Brain Tumor Pathol. 2016 Jul;33(3):222-7. doi: 10.1007/s10014-016-0257-5. Epub 2016 Mar 9. PubMed PMID: 26960334; PubMed Central PMCID: PMC5605295.

    7. Sun SQ, Cai C, Murphy RK, DeWees T, Dacey RG, Grubb RL, Rich KM, Zipfel GJ, Dowling JL, Leuthardt EC, Simpson JR, Robinson CG, Chicoine MR, Perrin RJ, Huang J, Kim AH. Radiation Therapy for Residual or Recurrent Atypical Meningioma: The Effects of Modality, Timing, and Tumor Pathology on Long-Term Outcomes. Neurosurgery. 2016 Jul;79(1):23-32. doi: 10.1227/NEU.0000000000001160. PubMed PMID: 26645969.

    8. Pan Y, Daito T, Sasaki Y, Chung YH, Xing X, Pondugula S, Swamidass SJ, Wang T, Kim AH, Yano H. Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity. Sci Rep. 2016 Aug 12;6:31022. doi: 10.1038/srep31022. PubMed PMID: 27516062; PubMed Central PMCID: PMC4981892.

    9. Pan Y, Daito T, Sasaki Y, Chung YH, Xing X, Pondugula S, Swamidass SJ, Wang T, Kim AH, Yano H. Erratum: Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity. Sci Rep. 2016 Sep 21;6:33766. doi: 10.1038/srep33766. PubMed PMID: 27649847; PubMed Central PMCID: PMC5030520.

    10. Dadey DY, Kamath AA, Smyth MD, Chicoine MR, Leuthardt EC, Kim AH. Utilizing personalized stereotactic frames for laser interstitial thermal ablation of posterior fossa and mesiotemporal brain lesions: a single-institution series. Neurosurg Focus. 2016 Oct;41(4):E4. doi: 10.3171/2016.7.FOCUS16207. PubMed PMID: 27690652.

    11. Sylvester PT, Moran CJ, Derdeyn CP, Cross DT, Dacey RG, Zipfel GJ, Kim AH, Uppaluri R, Haughey BH, Tempelhoff R, Rich KM, Schneider J, Chole RA, Chicoine MR. Endovascular management of internal carotid artery injuries secondary to endonasal surgery: case series and review of the literature. J Neurosurg. 2016 Nov;125(5):1256-1276. doi: 10.3171/2015.6.JNS142483. Epub 2016 Jan 15. Review. PubMed PMID: 26771847.

    12. Gujar AD, Le S, Mao DD, Dadey DY, Turski A, Sasaki Y, Aum D, Luo J, Dahiya S, Yuan L, Rich KM, Milbrandt J, Hallahan DE, Yano H, Tran DD, Kim AH. An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):E8247-E8256. doi: 10.1073/pnas.1610921114. Epub 2016 Dec 7. PubMed PMID: 27930300; PubMed Central PMCID: PMC5187672.

    2015

    1.             Speirs CK, Simpson JR, Robinson CG, DeWees TA, Tran DD, Linette G, Chicoine MR, Dacey RG, Rich KM, Dowling JL, Leuthardt EC, Zipfel GJ, Kim AH, Huang J. Impact of 1p/19q codeletion and histology on outcomes of anaplastic gliomas treated with radiation therapy and temozolomide. Int J Radiat Oncol Biol Phys. 2015 Feb 1;91(2):268-76. doi: 10.1016/j.ijrobp.2014.10.027. PubMed PMID: 25636755. 

    2.             Sylvester PT, Evans JA, Zipfel GJ, Chole RA, Uppaluri R, Haughey BH, Getz AE, Silverstein J, Rich KM, Kim AH, Dacey RG, Chicoine MR.Combined high-field intraoperative magnetic resonance imaging and endoscopy increase extent of resection and progression-free survival for pituitary adenomas. Pituitary. 2015 Feb;18(1):72-85. doi: 10.1007/s11102-014-0560-2. PubMed PMID: 24599833; PubMed Central PMCID: PMC4161669. 

    3.             Sun SQ, Hawasli AH, Huang J, Chicoine MR, Kim AH. An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas. Neurosurg Focus. 2015 Mar;38(3):E3. doi: 10.3171/2015.1.FOCUS14757. Review. PubMed PMID: 25727225. 

    4.             Zygourakis CC, Vasudeva V, Lai PM, Kim AH, Wang H, Du R. Transient pupillary dilation following local papaverine application in intracranial aneurysm surgery. J Clin Neurosci. 2015 Apr;22(4):676-9. doi: 10.1016/j.jocn.2014.10.016. Epub 2015 Jan 3. PubMed PMID: 25564265. 

    5.             Sun SQ, Cai C, Ravindra VM, Gamble P, Yarbrough CK, Dacey RG, Dowling JL, Zipfel GJ, Wright NM, Santiago P, Robinson CG, Schmidt MH, Kim AH, Ray WZ. Simpson Grade I-III Resection of Spinal Atypical (World Health Organization Grade II) Meningiomas is Associated With Symptom Resolution and Low Recurrence. Neurosurgery. 2015 Jun;76(6):739-46. doi: 10.1227/NEU.0000000000000720. PubMed PMID: 25774702. 

    6.             Mao DD, Gujar AD, Mahlokozera T, Chen I, Pan Y, Luo J, Brost T, Thompson EA, Turski A, Leuthardt EC, Dunn GP, Chicoine MR, Rich KM, Dowling JL, Zipfel GJ, Dacey RG, Achilefu S, Tran DD, Yano H, Kim AH. A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells. Cell Rep. 2015 Jun 23;11(11):1809-21. doi: 10.1016/j.celrep.2015.05.027. Epub 2015 Jun 11. PubMed PMID: 26074073; PubMed Central PMCID: PMC4481182. 

    7.             Sengupta R, Barone A, Marasa J, Taylor S, Jackson E, Warrington NM, Rao S, Kim AH, Leonard JR, Piwnica-Worms D, Rubin JB. Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions. Oncotarget. 2015 Jul 30;6(21):18282-92. doi: 10.18632/oncotarget.4957. PubMed PMID: 26286961; PubMed Central PMCID: PMC4621891. 

    8.             Huang J, DeWees TA, Badiyan SN, Speirs CK, Mullen DF, Fergus S, Tran DD, Linette G, Campian JL, Chicoine MR, Kim AH, Dunn G, Simpson JR, Robinson CG. Clinical and Dosimetric Predictors of Acute Severe Lymphopenia During Radiation Therapy and Concurrent Temozolomide for High-Grade Glioma. Int J Radiat Oncol Biol Phys. 2015 Aug 1;92(5):1000-1007. doi: 10.1016/j.ijrobp.2015.04.005. Epub 2015 Apr 8. PubMed PMID: 26025775. 

    2014

    1. Lin AL, Liu J, Evans J, Leuthardt EC, Rich KM, Dacey RG, Dowling JL, Kim AH, Zipfel GJ, Grubb RL, Huang J, Robinson CG, Simpson JR, Linette GP, Chicoine MR, Tran DD. Codeletions at 1p and 19q predict a lower risk of pseudoprogression in oligodendrogliomas and mixed oligoastrocytomas. Neuro Oncol. 2014 Jan;16(1):123-30. doi: 10.1093/neuonc/not142. Epub 2013 Nov 26. PubMed PMID: 24285548; PubMed Central PMCID: PMC3870829.

    2. Fouke SJ, Benzinger TL, Milchenko M, LaMontagne P, Shimony JS, Chicoine MR, Rich KM, Kim AH, Leuthardt EC, Keogh B, Marcus DS.The comprehensive neuro-oncology data repository (CONDR): a research infrastructure to develop and validate imaging biomarkers. Neurosurgery. 2014 Jan;74(1):88-98. doi: 10.1227/NEU.0000000000000201. PubMed PMID: 24089052; PubMed Central PMCID: PMC4627592.

    3. Yano H, Baranov SV, Baranova OV, Kim J, Pan Y, Yablonska S, Carlisle DL, Ferrante RJ, Kim AH, Friedlander RM. Inhibition of mitochondrial protein import by mutant huntingtin. Nat Neurosci. 2014 Jun;17(6):822-31. doi: 10.1038/nn.3721. Epub 2014 May 18. PubMed PMID: 24836077; PubMed Central PMCID: PMC4174557.

    4. Brooks MD, Jackson E, Warrington NM, Luo J, Forys JT, Taylor S, Mao DD, Leonard JR, Kim AH, Piwnica-Worms D, Mitra RD, Rubin JB.PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells.PLoS One. 2014;9(9):e107397. doi: 10.1371/journal.pone.0107397. eCollection 2014. PubMed PMID: 25203500; PubMed Central PMCID: PMC4159344.

    5. Sun SQ, Kim AH, Cai C, Murphy RK, DeWees T, Sylvester P, Dacey RG, Grubb RL, Rich KM, Zipfel GJ, Dowling JL, Leuthardt EC, Leonard JR, Evans J, Simpson JR, Robinson CG, Perrin RJ, Huang J, Chicoine MR. Management of atypical cranial meningiomas, part 1: predictors of recurrence and the role of adjuvant radiation after gross total resection. Neurosurgery. 2014 Oct;75(4):347-54; discussion 354-5; quiz 355. doi: 10.1227/NEU.0000000000000461. PubMed PMID: 24932707.

    6. Kim AH, Thompson EA, Governale LS, Santa C, Cahll K, Kieran MW, Chi SN, Ullrich NJ, Scott RM, Goumnerova LC. Recurrence after gross-total resection of low-grade pediatric brain tumors: the frequency and timing of postoperative imaging. J Neurosurg Pediatr.2014 Oct;14(4):356-64. doi: 10.3171/2014.6.PEDS1321. Epub 2014 Jul 25. PubMed PMID: 25062303; PubMed Central PMCID: PMC4858166.

    7. Sun SQ, Cai C, Murphy RK, DeWees T, Dacey RG, Grubb RL, Rich KM, Zipfel GJ, Dowling JL, Leuthardt EC, Leonard JR, Evans J, Simpson JR, Robinson CG, Perrin RJ, Huang J, Chicoine MR, Kim AH. Management of atypical cranial meningiomas, part 2: predictors of progression and the role of adjuvant radiation after subtotal resection. Neurosurgery. 2014 Oct;75(4):356-63; discussion 363. doi: 10.1227/NEU.0000000000000462. PubMed PMID: 24932708.

    8. Garsa AA, Badiyan SN, DeWees T, Simpson JR, Huang J, Drzymala RE, Barani IJ, Dowling JL, Rich KM, Chicoine MR, Kim AH, Leuthardt EC, Robinson CG. Predictors of individual tumor local control after stereotactic radiosurgery for non-small cell lung cancer brain metastases. Int J Radiat Oncol Biol Phys. 2014 Oct 1;90(2):407-13. doi: 10.1016/j.ijrobp.2014.05.047. Epub 2014 Jul 30. PubMed PMID: 25084610.

    9. Badiyan SN, Markovina S, Simpson JR, Robinson CG, DeWees T, Tran DD, Linette G, Jalalizadeh R, Dacey R, Rich KM, Chicoine MR, Dowling JL, Leuthardt EC, Zipfel GJ, Kim AH, Huang J. Radiation therapy dose escalation for glioblastoma multiforme in the era of temozolomide. Int J Radiat Oncol Biol Phys. 2014 Nov 15;90(4):877-85. doi: 10.1016/j.ijrobp.2014.07.014. Epub 2014 Sep 23. PubMed PMID: 25257812.

    10. Hawasli AH, Kim AH, Dunn GP, Tran DD, Leuthardt EC. Stereotactic laser ablation of high-grade gliomas. Neurosurg Focus. 2014 Dec;37(6):E1. doi: 10.3171/2014.9.FOCUS14471. Review. PubMed PMID: 25434378.

    11. Aum DJ, Kim DH, Beaumont TL, Leuthardt EC, Dunn GP, Kim AH. Molecular and cellular heterogeneity: the hallmark of glioblastoma.Neurosurg Focus. 2014 Dec;37(6):E11. doi: 10.3171/2014.9.FOCUS14521. Review. PubMed PMID: 25434380.

    2013

    1. Puram SV, Kim AH, Park HY, Anckar J, Bonni A. The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain. Cell Rep. 2013 Jul 11;4(1):19-30. doi: 10.1016/j.celrep.2013.06.006. Epub 2013 Jul 3. PubMed PMID: 23831032; PubMed Central PMCID: PMC4103748.

    Other notable studies

    1. Kong H, Kim AH, Orlinick JR, Chao MV. A comparison of the cytoplasmic domains of the Fas receptor and the p75 neurotrophin receptor. Cell Death Differ. 1999 Nov;6(11):1133-42. PubMed PMID: 10578183.
    2. Kim AH, Sheline CT, Tian M, Higashi T, McMahon RJ, Cousins RJ, Choi DW. L-type Ca(2+) channel-mediated Zn(2+) toxicity and modulation by ZnT-1 in PC12 cells. Brain Res. 2000 Dec 15;886(1-2):99-107. PubMed PMID: 11119691.
    3. Kim AH, Khursigara G, Sun X, Franke TF, Chao MV. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol. 2001 Feb;21(3):893-901. PubMed PMID: 11154276; PubMed Central PMCID: PMC86680.
    4. Lee FS, Kim AH, Khursigara G, Chao MV. The uniqueness of being a neurotrophin receptor. Curr Opin Neurobiol. 2001 Jun;11(3):281-6. PubMed PMID: 11399425.
    5. Lee FS, Rajagopal R, Kim AH, Chang PC, Chao MV. Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides. J Biol Chem. 2002 Mar 15;277(11):9096-102. PubMed PMID: 11784714.
    6. Kim AH, Yano H, Cho H, Meyer D, Monks B, Margolis B, Birnbaum MJ, Chao MV. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron. 2002 Aug 15;35(4):697-709. PubMed PMID: 12194869.
    7. Kim AH, Sasaki T, Chao MV. JNK-interacting protein 1 promotes Akt1 activation. J Biol Chem. 2003 Aug 8;278(32):29830-6. PubMed PMID: 12783873.
    8. Kim AH, Bonni A. Thinking within the D box: initial identification of Cdh1-APC substrates in the nervous system. Mol Cell Neurosci. 2007 Mar;34(3):281-7. PubMed PMID: 17223572.
    9. Kim AH, Bonni A. Cdk1-FOXO1: a mitotic signal takes center stage in post-mitotic neurons. Cell Cycle. 2008 Dec 15;7(24):3819-22. PubMed PMID: 19124971; PubMed Central PMCID: PMC2868071.
    10. Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, Rowitch D, Bonni A. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell. 2009 Jan 23;136(2):322-36. PubMed PMID: 19167333; PubMed Central PMCID: PMC2707082.
    11. Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, Chiba AA, Tuszynski MH. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009 Mar;15(3):331-7. PubMed PMID: 19198615; PubMed Central PMCID: PMC2838375.
    12. Yang Y, Kim AH, Yamada T, Wu B, Bilimoria PM, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science. 2009 Oct 23;326(5952):575-8. PubMed PMID: 19900895; PubMed Central PMCID: PMC2846784.
    13. Puram SV, Kim AH, Bonni A. An old dog learns new tricks: a novel function for Cdc20-APC in dendrite morphogenesis in neurons. Cell Cycle. 2010 Feb 1;9(3):482-5. PubMed PMID: 20195072; PubMed Central PMCID: PMC2853878.
    14. Yang Y, Kim AH, Bonni A. The dynamic ubiquitin ligase duo: Cdh1-APC and Cdc20-APC regulate neuronal morphogenesis and connectivity. Curr Opin Neurobiol. 2010 Feb;20(1):92-9. PubMed PMID: 20060286; PubMed Central PMCID: PMC3118470.
    15. Puram SV, Kim AH, Ikeuchi Y, Wilson-Grady JT, Merdes A, Gygi SP, Bonni A. A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain. Nat Neurosci. 2011 Jul 3;14(8):973-83. PubMed PMID: 21725312; PubMed Central PMCID: PMC3391735.
    16. Puram SV, Riccio A, Koirala S, Ikeuchi Y, Kim AH, Corfas G, Bonni A. A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brain. Genes Dev. 2011 Dec 15;25(24):2659-73. PubMed PMID: 22135323; PubMed Central PMCID: PMC3248686.

  • Gallery

    Photos from lab events

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    Lab meeting, 2018
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    Genetics Holiday Party, 2018
    Kim and Yano Holiday Party, 2018
    Kim and Yano Holiday Party, 2018
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    Kim and Yano labs, 2013
    Albert Kim, Diane Mao, Anne Thompson, 2012
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